Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array

Neural recording and stimulation of dissociated hippocampal cultures using microfabricated three-dimensional tip electrode array.

There is increasing interest in interfacing dissociated neuronal cultures with planar multielectrode arrays (MEAs) for the study of the dynamics of neuronal networks. Here we report on the successful use of three-dimensional tip electrode arrays (3D MEAs), originally developed for use with brain slices, for recording and stimulation of cultured neurons. We observed that many neurons grew direct...

Human Cell-Based Micro Electrode Array Platform for Studying Neurotoxicity

At present, most of the neurotoxicological analyses are based on in vitro and in vivo models utilizing animal cells or animal models. In addition, the used in vitro models are mostly based on molecular biological end-point analyses. Thus, for neurotoxicological screening, human cell-based analysis platforms in which the functional neuronal networks responses for various neurotoxicants can be al...

A carbon-fiber electrode array for long-term neural recording.

OBJECTIVE Chronic neural recording in behaving animals is an essential method for studies of neural circuit function. However, stable recordings from small, densely packed neurons remains challenging, particularly over time-scales relevant for learning. APPROACH We describe an assembly method for a 16-channel electrode array consisting of carbon fibers (<5 µm diameter) individually insulated ...

Analysis of Cardiac Myocyte Activity Dynamics with Micro-Electrode Arrays

Controllable in-situ cell electroporation with cell positioning and impedance monitoring using micro electrode array

This paper reports a novel microarray chip for in-situ, real-time and selective electroporation on individual cells integrated with cell positioning and impedance monitoring. An array of quadrupole-electrode units (termed positioning electrodes) and pairs of planar center electrodes located at the centers of each quadrupole-electrode unit were fabricated on the chip. The positioning electrodes ...